Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 20/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 16/20 | 0.48 |
| ▸ | TSPO | P30536 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3417972 | 0.93 | HCRTR1 (0.56) | HCRTR1HCRTR2TSPOOPRK1HTR2B | |
| SCHEMBL2924770 | 0.93 | HCRTR1 (0.56) | HCRTR1HCRTR2TSPOOPRK1HTR2B | |
| SCHEMBL3415378 | 0.91 | HCRTR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL3413935 | 0.87 | HCRTR1 (0.46) | HCRTR1HCRTR2TSPOOPRK1HTR2B | |
| SCHEMBL3412058 | 0.87 | HCRTR1 (0.46) | HCRTR1HCRTR2TSPOOPRK1HTR2B | |
| SCHEMBL2928072 | 0.87 | HCRTR1 (0.46) | HCRTR1HCRTR2TSPOOPRK1HTR2B | |
| SCHEMBL3418012 | 0.86 | HCRTR1 (0.47) | HCRTR1HCRTR2TSPOOPRK1HTR2B | |
| SCHEMBL3415254 | 0.85 | HCRTR1 (0.43) | HCRTR1HCRTR2 | |
| SCHEMBL2931302 | 0.85 | HCRTR1 (0.51) | HCRTR1HCRTR2 | |
| SCHEMBL3413236 | 0.85 | HCRTR1 (0.47) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | disclosed |