Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 3/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 7/20 | 0.38 |
| ▸ | CDK4 | P11802 | 6/20 | 0.38 |
| ▸ | CCND1 | P24385 | 6/20 | 0.38 |
| ▸ | CDK2 | P24941 | 6/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3418538 | 1.00 | GRM5 (0.43) | GRM5MAPK8SYKJUNMAPK10 | |
| SCHEMBL1334044 | 0.88 | GRM5 (0.40) | GRM5SYKJUNMAPK10PSEN1 | |
| SCHEMBL1334045 | 0.88 | GRM5 (0.40) | GRM5SYKJUNMAPK10PSEN1 | |
| SCHEMBL1034756 | 0.85 | GRM5 (0.39) | GRM5MAPK8SYKJUNMAPK10 | |
| SCHEMBL1033033 | 0.85 | GRM5 (0.39) | GRM5MAPK8SYKJUNMAPK10 | |
| SCHEMBL1033032 | 0.85 | GRM5 (0.39) | GRM5MAPK8SYKJUNMAPK10 | |
| SCHEMBL1034758 | 0.85 | GRM5 (0.39) | GRM5MAPK8SYKJUNMAPK10 | |
| SCHEMBL1334229 | 0.83 | MAPK8 (0.41) | GRM5MAPK8SYKJUNMAPK10 | |
| SCHEMBL1334231 | 0.83 | MAPK8 (0.41) | GRM5MAPK8SYKJUNMAPK10 | |
| SCHEMBL1032779 | 0.83 | GRM5 (0.37) | GRM5SYKPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068863-A2 | PYRIMIDINE COMPOUNDS AND METHODS OF MAKING AND USING SAME | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2010-06-17 | — | — | WO | disclosed |