Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 15/20 | 0.69 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | GNRHR | P30968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4156940 | 0.95 | CASR (0.76) | CASRNR1I2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3344800 | 0.90 | CASR (0.74) | CASRNR1I2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3417987 | 0.89 | CASR (0.65) | CASRNR1I2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3387584 | 0.88 | CASR (0.61) | CASRNR1I2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3348571 | 0.88 | CASR (0.65) | CASRNR1I2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4153069 | 0.88 | CASR (0.62) | CASRNR1I2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3343271 | 0.88 | CASR (0.79) | CASRNR1I2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3346123 | 0.88 | CASR (0.66) | CASRNR1I2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4155635 | 0.87 | CASR (0.65) | CASRNR1I2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3344719 | 0.87 | CASR (0.63) | CASRNR1I2ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010065383-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-06-10 | — | — | WO | disclosed |