Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.58 |
| ▸ | KIT | P10721 | 18/20 | 0.58 |
| ▸ | FLT3 | P36888 | 18/20 | 0.58 |
| ▸ | AURKA | O14965 | 6/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.54 |
| ▸ | PLK4 | O00444 | 5/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.54 |
| ▸ | CSF1R | P07333 | 5/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.54 |
| ▸ | FLT1 | P17948 | 5/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.54 |
| ▸ | FLT4 | P35916 | 5/20 | 0.54 |
| ▸ | STK3 | Q13188 | 5/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.54 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.54 |
| ▸ | MARK2 | Q7KZI7 | 5/20 | 0.54 |
| ▸ | LYN | P07948 | 4/20 | 0.54 |
| ▸ | MARK3 | P27448 | 4/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 4/20 | 0.54 |
| ▸ | SGK2 | Q9HBY8 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL421915 | 0.86 | KIT (0.71) | KDRKITFLT3AURKAAURKB | |
| SCHEMBL420875 | 0.83 | KDR (0.77) | KDRKITFLT3AURKAAURKB | |
| SCHEMBL425738 | 0.79 | AURKB (0.76) | KDRKITFLT3AURKAAURKB | |
| SCHEMBL423070 | 0.78 | KDR (0.76) | KDRKITFLT3AURKAAURKB | |
| SCHEMBL423321 | 0.78 | KDR (0.80) | KDRKITFLT3AURKAAURKB | |
| SCHEMBL423364 | 0.78 | KDR (0.76) | KDRKITFLT3AURKAAURKB | |
| SCHEMBL425755 | 0.78 | KDR (0.77) | KDRKITFLT3AURKAAURKB | |
| SCHEMBL423368 | 0.76 | KDR (0.77) | KDRKITFLT3AURKAAURKB | |
| SCHEMBL419045 | 0.76 | KDR (0.76) | KDRKITFLT3AURKAAURKB | |
| SCHEMBL422816 | 0.75 | KDR (0.79) | KDRKITFLT3AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246333-A1 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | Abbott Laboratories (US) | 2010-11-03 | — | — | EP | disclosed |