Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 2/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.55 |
| ▸ | EGFR | P00533 | 15/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.55 |
| ▸ | GAK | O14976 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.52 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13514716 | 0.88 | HDAC3 (0.69) | FBP1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1766074 | 0.88 | EGFR (0.55) | FBP1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1766071 | 0.84 | EGFR (0.72) | FBP1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL256391 | 0.77 | EGFR (0.61) | FBP1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12426823 | 0.76 | EGFR (0.69) | FBP1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL19885307 | 0.76 | EGFR (0.68) | EGFRERBB2ERBB4AURKARIPK2 | |
| SCHEMBL642238 | 0.76 | EGFR (0.71) | FBP1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL15338357 | 0.76 | EGFR (0.66) | EGFRERBB2ERBB4LCKRET | |
| SCHEMBL1999903 | 0.75 | EGFR (0.74) | FBP1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20865319 | 0.74 | EGFR (0.67) | FBP1HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012000356-A1 | QUINAZOLINE COMPOUNDS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-01-05 | — | — | WO | disclosed |
| WO-2012000182-A1 | QUINAZOLINE COMPOUNDS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-01-05 | — | — | WO | disclosed |