Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 13/20 | 0.58 |
| ▸ | KIT | P10721 | 4/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15667853 | 0.89 | ENPP1 (0.60) | PDGFRBKITACHEBACE1ENPP1 | |
| SCHEMBL7154779 | 0.87 | KIT (0.57) | PDGFRBKITACHEBACE1ENPP1 | |
| SCHEMBL4542484 | 0.84 | PDGFRB (0.84) | PDGFRBKITFLT3 | |
| SCHEMBL906257 | 0.82 | PDGFRB (0.65) | PDGFRBKITFLT3 | |
| SCHEMBL6428983 | 0.82 | PDGFRB (0.72) | PDGFRBKITFLT3 | |
| SCHEMBL6709598 | 0.82 | PDGFRB (0.55) | PDGFRBKIT | |
| SCHEMBL2387940 | 0.82 | PDGFRB (0.72) | PDGFRBKIT | |
| SCHEMBL906254 | 0.81 | PDGFRB (0.72) | PDGFRBKITFLT3 | |
| SCHEMBL3315762 | 0.81 | PDGFRB (0.72) | PDGFRBKITFLT3 | |
| SCHEMBL6709600 | 0.81 | PDGFRB (0.57) | PDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904459-A1 | NEW CRYSTAL FORMS OF 4-[6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)QUINAZOLIN-4-YL]PIPERAZINE-1-CARBOXYLIC ACID(4-ISOPROPOXYPHENYL)-AMIDE | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-04-02 | — | — | EP | claimed |
| WO-2007012042-A1 | NEW CRYSTAL FORMS OF 4-[6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)QUINAZOLIN-4-YL]PIPERAZINE-1-CARBOXYLIC ACID(4-ISOPROPOXYPHENYL)-AMIDE | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-01-25 | — | — | WO | claimed |
| WO-2010059239-A2 | LACTATE SALT OF 4-(6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)QUINAZOLIN-4-YL]PIPERAZINE-1-CARBOXYLIC ACID(4-ISOPROPOXYPHENYL)-AMIDE AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CANCER AND OTHER DISEASES OR DISORDERS | MILLENNIUM PHARMACEUTICALS, INC (US) | 2010-05-27 | — | — | WO | disclosed |
| EP-1904459-A1 | NEW CRYSTAL FORMS OF 4-[6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)QUINAZOLIN-4-YL]PIPERAZINE-1-CARBOXYLIC ACID(4-ISOPROPOXYPHENYL)-AMIDE | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007012042-A1 | NEW CRYSTAL FORMS OF 4-[6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)QUINAZOLIN-4-YL]PIPERAZINE-1-CARBOXYLIC ACID(4-ISOPROPOXYPHENYL)-AMIDE | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-01-25 | — | — | WO | disclosed |