Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.66 |
| ▸ | FLT3 | P36888 | 14/20 | 0.66 |
| ▸ | KIT | P10721 | 12/20 | 0.66 |
| ▸ | CSF1R | P07333 | 10/20 | 0.66 |
| ▸ | FLT4 | P35916 | 10/20 | 0.66 |
| ▸ | LYN | P07948 | 9/20 | 0.66 |
| ▸ | FLT1 | P17948 | 9/20 | 0.66 |
| ▸ | SRC | P12931 | 8/20 | 0.66 |
| ▸ | BLK | P51451 | 8/20 | 0.66 |
| ▸ | LCK | P06239 | 8/20 | 0.66 |
| ▸ | FYN | P06241 | 6/20 | 0.66 |
| ▸ | ABL1 | P00519 | 4/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.59 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.58 |
| ▸ | PLK4 | O00444 | 3/20 | 0.58 |
| ▸ | AURKA | O14965 | 3/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.58 |
| ▸ | CDK1 | P06493 | 3/20 | 0.58 |
| ▸ | MET | P08581 | 3/20 | 0.58 |
| ▸ | PRKACA | P17612 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL422809 | 0.90 | KDR (0.75) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL3394287 | 0.87 | KDR (0.69) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL421150 | 0.86 | KDR (0.79) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL425326 | 0.85 | KDR (0.75) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL423148 | 0.84 | KDR (0.82) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL420765 | 0.80 | KDR (1.00) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL424290 | 0.79 | KDR (0.78) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL419459 | 0.79 | KDR (1.00) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL425759 | 0.79 | KDR (0.74) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL3422842 | 0.78 | KDR (0.56) | KDRFLT3KITCSF1RFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246333-A1 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | Abbott Laboratories (US) | 2010-11-03 | — | — | EP | disclosed |