SCHEMBL342317

SCHEMBL342317

O=C1NC2(CCCCC2)C(=O)C1c1c(Cl)cc(OC(F)(F)F)cc1Cl

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PDE7A Q13946 9/20 0.37
FFAR4 Q5NUL3 7/20 0.33
DRD3 P35462 1/20 0.32
SLC6A2 P23975 1/20 0.32
SLC6A4 P31645 1/20 0.32
SLC6A3 Q01959 1/20 0.32
CES1 P23141 1/20 0.32
ADCYAP1R1 P41586 1/20 0.30
SCN9A Q15858 1/20 0.30
PDE7B Q9NP56 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL342336 0.84 CES1 (0.32) SLC6A2SLC6A4SLC6A3CES1ADCYAP1R1
SCHEMBL343189 0.80 FFAR4 (0.33) FFAR4DRD3CES1
SCHEMBL12496990 0.73 PDE7A (0.43) PDE7ACES1PDE7B
SCHEMBL16562535 0.72 PDE7A (0.33) PDE7A
SCHEMBL1812688 0.72 PDE7A (0.44) PDE7A
SCHEMBL5929431 0.72 PDE7A (0.41) PDE7APDE7B
SCHEMBL342154 0.71 HCRTR1 (0.36)
SCHEMBL12496896 0.71 PDE7A (0.40) PDE7ACES1
SCHEMBL4428399 0.71 PDE7A (0.47) PDE7APDE7B
SCHEMBL1721097 0.71 MAPT (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8507537-B2 Trifluromethoxyphenyl-substituted tetramic acid derivatives pesticides and/or herbicides BAYER CROPSCIENCE AG (DE) 2013-08-13 US disclosed
US-20120015807-A1 Trifluromethoxyphenyl-Substituted Tetramic Acid Derivatives Pesticides and/or Herbicides BAYER CROPSCIENCE AG (DE) 2012-01-19 US disclosed
EP-2121597-B1 TRIFLUOROMETHOXYPHENYL-SUBSTITUTED TETRAMIC ACID DERIVATIVES AS PESTICIDES AND/OR HERBICIDES BAYER CROPSCIENCE AG (DE) 2011-09-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120015807-A1 Trifluromethoxyphenyl-Substituted Tetramic Acid Derivatives Pesticides and/or Herbicides DDT, PTPRG, SLC1A5 PDE7A 2015/4885FFAR4 1690/4885DRD3 1865/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.