Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.52 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3425897 | 0.90 | MAP2K1 (0.52) | MAP2K1MAP2K2ABCB11NQO2ALDH1A1 | |
| SCHEMBL3424588 | 0.84 | MAP2K1 (0.47) | MAP2K1MAP2K2ABCB11NQO2ALDH1A1 | |
| SCHEMBL3429349 | 0.78 | MAP2K1 (0.44) | MAP2K1MAP2K2ALDH1A1L3MBTL1 | |
| SCHEMBL3426579 | 0.77 | MAP2K1 (0.49) | MAP2K1MAP2K2ABCB11NQO2ALDH1A1 | |
| SCHEMBL29669434 | 0.77 | MAP2K1 (0.47) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL28759970 | 0.77 | MAP2K1 (0.47) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL3425476 | 0.77 | MAP2K1 (0.47) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL3426587 | 0.77 | MAP2K1 (0.47) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL3426067 | 0.76 | MAP2K1 (0.46) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL388765 | 0.76 | MAP2K1 (0.53) | MAP2K1MAP2K2ABCB11NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689233-B1 | BICYCLIC INHIBITORS OF MEK | ARRAY BIOPHARMA INC (US) | 2012-07-04 | — | — | EP | disclosed |
| US-7772234-B2 | 7-(2,4-Dichlorophenylamino)-8-fluoro-4-methyl-cinnoline-6-carboxylic acid (2-hydroxyethoxy)-amide; mitogen activated protein, extracellular signal regulated kinase, kinase inhibitor; cancer and inflammation | ARRAY BIOPHARMA INC. (US) | 2010-08-10 | — | — | US | disclosed |
| EP-1689233-A4 | BICYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2007-08-29 | — | — | EP | disclosed |
| EP-1689233-A2 | BICYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2006-08-16 | — | — | EP | disclosed |
| US-20050130976-A1 | Bicyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA INC. | 2005-06-16 | — | — | US | disclosed |
| WO-2005051302-A2 | BICYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2005-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130976-A1 | Bicyclic inhibitors of MEK and methods of use thereof | NRAS, BRAF, RAF1 | MAP2K1 33/4885MAP2K2 26/4885ABCB11 1567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.