Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Mepivacaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mepivacaine SCHEMBL1131771 | 1.00 | KCNK3 (0.70) | KCNK3LMNACYP3A4CYP2D6KCNH2 | |
| Dexivacaine SCHEMBL34247 | 1.00 | KCNK3 (0.70) | KCNK3LMNACYP3A4CYP2D6KCNH2 | |
| Mepivacaine SCHEMBL30335090 | 1.00 | KCNK3 (0.70) | KCNK3LMNACYP3A4CYP2D6KCNH2 | |
| Mepivacaine SCHEMBL34246 | 0.99 | KCNK3 (0.72) | KCNK3LMNACYP3A4CYP2D6KCNH2 | |
| Mepivacaine SCHEMBL25314 | 0.99 | KCNK3 (0.72) | KCNK3LMNACYP3A4CYP2D6KCNH2 | |
| Dexivacaine SCHEMBL25315 | 0.99 | KCNK3 (0.72) | KCNK3LMNACYP3A4CYP2D6KCNH2 | |
| Mepivacaine SCHEMBL2565234 | 0.97 | KCNK3 (0.70) | KCNK3LMNACYP3A4CYP2D6KCNH2 | |
| Mepivacaine SCHEMBL5685622 | 0.97 | KCNK3 (0.70) | KCNK3LMNACYP3A4CYP2D6KCNH2 | |
| Mepivacaine SCHEMBL2553896 | 0.96 | KCNK3 (0.69) | KCNK3LMNACYP3A4CYP2D6KCNH2 | |
| SCHEMBL18485518 | 0.94 | CYP3A4 (0.74) | KCNK3LMNACYP3A4CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3164 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432401-B1 | — | — | None | — | — | US | claimed |
| EP-4743122-A1 | THERAPEUTIC SEALANTS BASED UPON DRUG CONJUGATES | The Johns Hopkins University (US) | 2026-05-20 | — | — | EP | claimed |
| US-20260021185-A1 | LOCAL ANESTHETIC SOLUTION FOR DENTAL AND/OR CONTRAST MEDIA USE | NEOCAINE LLC (US) | 2026-01-22 | — | — | US | claimed |
| EP-4661897-A1 | METHODS AND COMPOSITIONS FOR SKIN REPAIR, REJUVENATION AND COMFORT | Lynch, Samuel (US) | 2025-12-17 | — | — | EP | claimed |
| US-20250319025-A9 | COMPOSITIONS COMPRISING MODIFIED PHOSPHOLIPIDS AND USES THEREOF | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2025-10-16 | — | — | US | claimed |
| WO-2025128639-A1 | HYDROGELS COMPRISING PROTEIN-STABILIZED NANOPARTICLES FOR EXTENDED RELEASE | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2025-06-19 | — | — | WO | claimed |
| WO-2025075976-A2 | METHYL-BRANCHED LIPOSOMES FOR SUSTAINED DRUG DELIVERY | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2025-04-10 | — | — | WO | claimed |
| WO-2025043046-A1 | LATEX-COMPATIBLE OIL-BASED COMPOSITIONS | GlycosBio, INC. (US) | 2025-02-27 | — | — | WO | claimed |
| US-20250049711-A1 | COMPOSITIONS COMPRISING MODIFIED PHOSPHOLIPIDS AND USES THEREOF | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2025-02-13 | — | — | US | claimed |
| US-20250032627-A1 | THERAPEUTIC SEALANTS BASED UPON DRUG CONJUGATES | INTEGRA LIFESCIENCES CORPORATION | 2025-01-30 | — | — | US | claimed |
| US-5322689-A | Topical aromatic releasing compositions | THE PROCTER & GAMBLE COMPANY (US) | 1994-06-21 | — | — | US | claimed |
| CN-1079896-A | The compositions of topical aromatic releasing | RICHARDSON VICKS INC (US) | 1993-12-29 | — | — | CN | claimed |
| WO-1993017655-A1 | TOPICAL AROMATIC RELEASING COMPOSITIONS | RICHARDSON VICKS INC. (US) | 1993-09-16 | — | — | WO | claimed |
| CN-1072863-A | Be used to improve the dermal osmosis system of the reinforcement of medicine localized delivery | RICHARDSON VICKS INC (US) | 1993-06-09 | — | — | CN | claimed |
| EP-0351897-A2 | Skin penetration system for salts of amine-functional drugs | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-24 | — | — | EP | claimed |
| US-4659714-A | PROLONGATION WITH VASOCONSTRICTORS; REVERSAL WITH ADRENERGIC BLOCKING AGENTS | DENTSPLY, LTD. (GB) | 1987-04-21 | — | — | US | claimed |
| EP-0160191-A1 | Kit for treating mammals | Dentsply Limited (GB) | 1985-11-06 | — | — | EP | claimed |
| US-4474748-A | ANTIBIOTICS, FUNGICIDES, ANTISEPTICS | JOHNSON & JOHNSON (US) | 1984-10-02 | — | — | US | claimed |
| US-4213876-A | Multi-purpose blood diluent for use in electronic blood analysis instrumentation | COULTER ELECTRONICS, INC. (US) | 1980-07-22 | — | — | US | claimed |
| US-4091090-A | PENETRANT ACCELERATOR COMPRISING CYCLOHEXYL-SUBSTITUTED ALKANOLS | JOHNSON & JOHNSON (US) | 1978-05-23 | — | — | US | claimed |