Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | FABP4 | P15090 | 8/20 | 0.46 |
| ▸ | FABP3 | P05413 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TOP1 | P11387 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2396353 | 0.83 | CHRM1 (0.59) | CHRM1FABP4FABP3LMNATOP1 | |
| SCHEMBL2396901 | 0.82 | TOP1 (0.40) | CHRM1FABP4LMNATOP1 | |
| SCHEMBL8010027 | 0.73 | CHRM1 (0.56) | CHRM1LMNATOP1 | |
| SCHEMBL4433121 | 0.72 | BRD4 (0.52) | LMNA | |
| SCHEMBL18284289 | 0.70 | SERPINE1 (0.46) | CHRM1LMNA | |
| SCHEMBL18284244 | 0.70 | CNR2 (0.47) | CHRM1LMNA | |
| SCHEMBL9022276 | 0.70 | CNR2 (0.47) | — | |
| SCHEMBL15519384 | 0.69 | MEN1 (0.38) | TOP1 | |
| SCHEMBL2397468 | 0.68 | CHRM1 (0.53) | CHRM1LMNATOP1 | |
| SCHEMBL15579846 | 0.68 | CHRM1 (0.52) | CHRM1LMNATOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252299-A1 | FUSED PYRIDONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck Sharp & Dohme Corp. (US) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009102588-A1 | FUSED PYRIDONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2009-08-20 | — | — | WO | disclosed |