Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13750912 | 0.96 | PDE4B (0.44) | PDE4BMAPK1PDE3BPDE7APDE3A | |
| SCHEMBL4347510 | 0.95 | PDE4B (0.45) | PDE4BMAPK1PDE3BPDE7APDE3A | |
| SCHEMBL4350308 | 0.95 | PDE4B (0.45) | PDE4BMAPK1PDE3BPDE7APDE3A | |
| SCHEMBL1362355 | 0.94 | PDE4B (0.47) | PDE4BMAPK1 | |
| SCHEMBL3430247 | 0.94 | PDE4B (0.47) | PDE4BMAPK1PDE3BPDE7APDE3A | |
| SCHEMBL3428333 | 0.93 | PDE4B (0.45) | PDE4BMAPK1 | |
| SCHEMBL3425060 | 0.93 | PDE4B (0.45) | PDE4BMAPK1ENPP2 | |
| SCHEMBL1362984 | 0.93 | PDE4B (0.46) | PDE4BPDE3BPDE7APDE3A | |
| SCHEMBL3426832 | 0.92 | PDE4B (0.51) | PDE4BMAPK1 | |
| SCHEMBL3428835 | 0.92 | PDE4B (0.44) | PDE4BMAPK1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2249830-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | Glaxo Group Limited (GB) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009100170-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009100170-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |