Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 5/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1895617 | 0.83 | JAK3 (0.60) | JAK3SYKCYP2C9NTRK1 | |
| SCHEMBL2275123 | 0.82 | JAK3 (0.62) | JAK3SYKCYP2C9 | |
| SCHEMBL2276612 | 0.82 | JAK3 (0.55) | JAK3SYKCYP2C9 | |
| SCHEMBL1713150 | 0.82 | JAK3 (0.49) | JAK3SYKCYP2C9 | |
| SCHEMBL2343991 | 0.82 | JAK3 (0.59) | JAK3SYKCYP2C9 | |
| SCHEMBL2280995 | 0.81 | JAK3 (0.61) | JAK3JAK2SYKCYP2C9 | |
| SCHEMBL2278825 | 0.81 | JAK3 (0.60) | JAK3JAK2SYKCYP2C9 | |
| SCHEMBL2278519 | 0.81 | JAK3 (0.46) | JAK3SYK | |
| SCHEMBL2273969 | 0.81 | JAK3 (0.58) | JAK3SYKCYP2C9 | |
| SCHEMBL2277589 | 0.81 | JAK3 (0.60) | JAK3SYKCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |