Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 9/20 | 0.77 |
| ▸ | CDK5R1 | Q15078 | 9/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MPO | P05164 | 2/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 5/20 | 0.34 |
| ▸ | GSK3A | P49840 | 4/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3426040 | 1.00 | CDK5 (0.77) | CDK5CDK5R1LMNAMPOXDH | |
| SCHEMBL13341183 | 1.00 | CDK5 (0.77) | CDK5CDK5R1LMNAMPOXDH | |
| SCHEMBL13341185 | 0.90 | CDK5 (0.73) | CDK5CDK5R1LMNANPC1RAB9A | |
| SCHEMBL3424360 | 0.90 | CDK5 (0.73) | CDK5CDK5R1LMNANPC1RAB9A | |
| SCHEMBL3424357 | 0.90 | CDK5 (0.73) | CDK5CDK5R1LMNANPC1RAB9A | |
| SCHEMBL3426086 | 0.87 | CDK5 (1.00) | CDK5CDK5R1LMNANPC1RAB9A | |
| SCHEMBL13341199 | 0.87 | CDK5 (1.00) | CDK5CDK5R1LMNANPC1RAB9A | |
| SCHEMBL3426089 | 0.87 | CDK5 (1.00) | CDK5CDK5R1LMNANPC1RAB9A | |
| SCHEMBL3426279 | 0.84 | CDK5 (0.75) | CDK5CDK5R1LMNANPC1RAB9A | |
| SCHEMBL3426282 | 0.84 | CDK5 (0.75) | CDK5CDK5R1LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713958-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2010-05-11 | — | — | US | claimed |
| US-20090137555-A1 | Compounds and Compositions as Protein Kinase Inhibitors | IRM LLC (BM) | 2009-05-28 | — | — | US | claimed |
| US-20050153955-A1 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2005-07-14 | — | — | US | claimed |
| WO-2004098520-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2004-11-18 | — | — | WO | claimed |
| US-7713958-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2010-05-11 | — | — | US | disclosed |
| US-20090137555-A1 | Compounds and Compositions as Protein Kinase Inhibitors | IRM LLC (BM) | 2009-05-28 | — | — | US | disclosed |
| US-7423031-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2008-09-09 | — | — | US | disclosed |
| US-20050153955-A1 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050153955-A1 | Compounds and compositions as protein kinase inhibitors | CDK1, CDK3, CDK11A | CDK5 16/4885CDK5R1 38/4885LMNA 1252/4885 |
| US-20090137555-A1 | Compounds and Compositions as Protein Kinase Inhibitors | CDK1, CDK3, CDK2 | CDK5 14/4885CDK5R1 37/4885LMNA 1085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.