Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 18/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4350271 | 0.97 | CHRM3 (0.45) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL4349706 | 0.97 | CHRM3 (0.45) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL4359345 | 0.96 | CHRM3 (0.44) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL4346723 | 0.96 | CHRM3 (0.44) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL4095127 | 0.95 | CHRM3 (0.46) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL4095343 | 0.95 | CHRM3 (0.46) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL1363863 | 0.95 | CHRM3 (0.51) | CHRM3CHRM2CHRM1KCNH2 | |
| SCHEMBL3425751 | 0.94 | PDE4B (0.43) | CHRM3PDE4B | |
| SCHEMBL1364318 | 0.93 | CHRM3 (0.47) | CHRM3CHRM2CHRM1PDE4BKCNH2 | |
| SCHEMBL1364111 | 0.93 | CHRM3 (0.47) | CHRM3CHRM2CHRM1PDE4BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2249830-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | Glaxo Group Limited (GB) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009100170-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009100170-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |