Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 8/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423406 | 0.78 | NOTUM (0.55) | NOTUM | |
| SCHEMBL4426056 | 0.77 | NOTUM (0.65) | NOTUM | |
| SCHEMBL4423495 | 0.76 | NOTUM (0.50) | NOTUMSMN1; SMN2 | |
| SCHEMBL4428903 | 0.76 | NOTUM (0.64) | NOTUMSMN1; SMN2MAP4K4ABL1HTT | |
| SCHEMBL4425317 | 0.76 | NOTUM (0.50) | NOTUMSMN1; SMN2CYP11B2ABL1 | |
| SCHEMBL4425073 | 0.76 | NOTUM (0.50) | NOTUM | |
| SCHEMBL4429333 | 0.75 | NOTUM (0.49) | NOTUMSMN1; SMN2CYP11B2MAP4K4MEN1 | |
| SCHEMBL4433531 | 0.75 | NOTUM (0.55) | NOTUMSMN1; SMN2ABL1 | |
| SCHEMBL27906474 | 0.75 | NOTUM (0.49) | NOTUMSMN1; SMN2CYP11B2MEN1KMT2A | |
| SCHEMBL4432842 | 0.72 | NOTUM (0.74) | NOTUMSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010011302-A1 | CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI, INC. (US) | 2010-01-28 | — | — | WO | disclosed |