Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 12/20 | 0.70 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.70 |
| ▸ | BUB1 | O43683 | 1/20 | 0.70 |
| ▸ | PRKACG | P22612 | 1/20 | 0.70 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.70 |
| ▸ | ACSL5 | Q9ULC5 | 1/20 | 0.70 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.70 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3533718 | 0.92 | MAPK14 (0.70) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL3412151 | 0.91 | MAPK14 (0.74) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL3538654 | 0.90 | MAPK14 (0.68) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL3425121 | 0.90 | MAPK14 (0.73) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL3535883 | 0.90 | MAPK14 (0.73) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL27598485 | 0.89 | MAPK14 (0.54) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL3407001 | 0.88 | MAPK14 (0.70) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL30335917 | 0.88 | MAPK14 (0.70) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL3406811 | 0.87 | MAPK14 (0.71) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL3539283 | 0.87 | MAPK14 (0.70) | MAPK14CYP2C9MAPK11BUB1PRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709506-B2 | Nicotinamide derivatives useful as p38 inhibitors | GLAXOSMITHKLINE LLC (US) | 2010-05-04 | — | — | US | disclosed |
| US-7125898-B2 | Nicotinamide derivatives useful as p38 inhibitors. | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-24 | — | — | US | disclosed |