Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3430169 | 0.97 | PDE4B (0.46) | PDE4BCHRM3 | |
| SCHEMBL1362509 | 0.91 | PDE4B (0.47) | PDE4BCHRM3 | |
| SCHEMBL3424876 | 0.89 | PDE4B (0.42) | PDE4BCHRM3 | |
| SCHEMBL1364042 | 0.88 | CHRM3 (0.50) | PDE4BCHRM3 | |
| SCHEMBL1362398 | 0.88 | PDE4B (0.46) | PDE4BCHRM3 | |
| SCHEMBL1362644 | 0.86 | PDE4B (0.49) | PDE4BCHRM3 | |
| SCHEMBL1364928 | 0.86 | PDE4B (0.48) | PDE4BCHRM3 | |
| SCHEMBL12141488 | 0.85 | CHRM3 (0.53) | PDE4BCHRM3 | |
| SCHEMBL1363852 | 0.85 | PDE4B (0.49) | PDE4BCHRM3 | |
| SCHEMBL3428983 | 0.84 | PDE4B (0.50) | PDE4BCHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2249647-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | Glaxo Group Limited (GB) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009100168-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |