SCHEMBL3427563

SCHEMBL3427563

Cc1c(N)c(Cc2ccco2)c(C2CCCCC2)c(C2CCCCC2)c1N

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP2 O75604 2/20 0.40
ALDH1A1 P00352 11/20 0.32
PNP P00491 1/20 0.32
NPSR1 Q6W5P4 5/20 0.32
TSHR P16473 4/20 0.32
LMNA P02545 4/20 0.32
GAA P10253 4/20 0.32
HSD17B10 Q99714 2/20 0.32
KMT2A Q03164 2/20 0.32
HPGD P15428 2/20 0.32
MEN1 O00255 1/20 0.32
POLB P06746 1/20 0.32
ALOX12 P18054 1/20 0.32
SMN1; SMN2 Q16637 3/20 0.31
TDP1 Q9NUW8 2/20 0.31
KDM4E B2RXH2 2/20 0.31
CHRNA1 P02708 1/20 0.31
CHRNA3 P32297 1/20 0.31
CHRNA7 P36544 1/20 0.31
HTR3A P46098 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19119097 0.90 USP2 (0.40) USP2ALDH1A1PNPNPSR1TSHR
SCHEMBL3395390 0.85 USP2 (0.44) USP2ALDH1A1PNPNPSR1TSHR
SCHEMBL4538488 0.84 USP2 (0.42) USP2ALDH1A1PNPNPSR1TSHR
SCHEMBL1499268 0.79 HPGD (0.35) USP2ALDH1A1NPSR1HSD17B10KMT2A
SCHEMBL3428404 0.76 USP2 (0.39) USP2ALDH1A1PNPNPSR1TSHR
SCHEMBL4538161 0.74 USP2 (0.37) USP2ALDH1A1PNPNPSR1TSHR
SCHEMBL3423940 0.73 CNR1 (0.32)
SCHEMBL1499188 0.70 CNR1 (0.36)
SCHEMBL3424791 0.70 CNR1 (0.33)
SCHEMBL1499208 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2245123-B1 METHODS FOR PRODUCING ALKYLATED 1,3 BENZENEDIAMINE COMPOUNDS CHEMTURA CORP (US) 2017-07-19 EP disclosed
EP-2245123-A2 ALKYLATED 1,3 BENZENEDIAMINE COMPOUNDS AND METHODS FOR PRODUCING SAME Chemtura Corporation (US) 2010-11-03 EP disclosed
WO-2009076091-A2 ALKYLATED 1,3 BENZENEDIAMINE COMPOUNDS AND METHODS FOR PRODUCING SAME CHEMTURA CORPORATION (US) 2009-06-18 WO disclosed