Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 10/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3428572 | 0.93 | F10 (0.47) | F10MAPK14 | |
| SCHEMBL3426427 | 0.91 | MAPK14 (0.39) | F10MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3427642 | 0.89 | F10 (0.49) | F10MAPK14 | |
| SCHEMBL3421824 | 0.87 | F10 (0.53) | F10 | |
| SCHEMBL3426826 | 0.86 | MAPK14 (0.40) | F10MAPK14 | |
| SCHEMBL3429300 | 0.85 | F10 (0.51) | F10 | |
| SCHEMBL3428698 | 0.84 | MAPK14 (0.38) | F10MAPK14 | |
| SCHEMBL3426030 | 0.81 | F10 (0.45) | F10MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3425883 | 0.80 | F10 (0.39) | F10MAPK14 | |
| SCHEMBL3424592 | 0.79 | F10 (0.77) | F10MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732466-B2 | Substituted thiophene carboxamides, process for their preparation and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-06-08 | — | — | US | disclosed |
| US-20060293300-A1 | New substituted thiophene carboxamides, process for their preparation and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293300-A1 | New substituted thiophene carboxamides, process for their preparation and their use as medicaments | OTC, TPMT, ABCG2 | F10 1901/4885MAPK14 3431/4885MAPK13 4258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.