Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 10/20 | 0.42 |
| ▸ | WDR5 | P61964 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4355924 | 0.95 | CHRM3 (0.45) | PDE4BCHRM3WDR5CHRM2CHRM1 | |
| SCHEMBL4358163 | 0.95 | PDE4B (0.44) | PDE4BCHRM3WDR5CHRM2CHRM1 | |
| SCHEMBL4347608 | 0.94 | PDE4B (0.43) | PDE4BCHRM3WDR5CHRM2CHRM1 | |
| SCHEMBL4355127 | 0.93 | CHRM3 (0.46) | PDE4BCHRM3WDR5CHRM2CHRM1 | |
| SCHEMBL13760233 | 0.93 | PDE4B (0.40) | PDE4BCHRM3CHRM2CHRM1 | |
| SCHEMBL4362683 | 0.92 | CHRM3 (0.45) | PDE4BCHRM3WDR5CHRM2CHRM1 | |
| SCHEMBL13750933 | 0.92 | PDE4B (0.43) | PDE4BCHRM3WDR5CHRM2CHRM1 | |
| SCHEMBL4351891 | 0.92 | PDE4B (0.45) | PDE4BCHRM3CHRM2CHRM1 | |
| SCHEMBL4350319 | 0.92 | PDE4B (0.45) | PDE4BCHRM3CHRM2CHRM1 | |
| SCHEMBL4087812 | 0.92 | PDE4B (0.46) | PDE4BCHRM3WDR5CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2249646-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | Glaxo Group Limited (GB) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009100169-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009100169-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |