Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 14/20 | 0.46 |
| ▸ | JAK2 | O60674 | 11/20 | 0.46 |
| ▸ | TYK2 | P29597 | 8/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 8/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL344026 | 0.91 | JAK1 (0.42) | JAK1JAK2TYK2HDAC6JAK3 | |
| SCHEMBL15428749 | 0.86 | JAK1 (0.47) | JAK1JAK2TYK2HDAC6JAK3 | |
| SCHEMBL10167391 | 0.84 | JAK1 (0.49) | JAK1JAK2TYK2HDAC6JAK3 | |
| SCHEMBL10167421 | 0.82 | HDAC6 (0.48) | JAK1JAK2TYK2HDAC6JAK3 | |
| SCHEMBL10207355 | 0.82 | JAK1 (0.47) | JAK1JAK2TYK2HDAC6JAK3 | |
| SCHEMBL342530 | 0.81 | CDK4 (0.47) | JAK2JAK3 | |
| SCHEMBL343335 | 0.81 | AURKA (0.43) | JAK1JAK3 | |
| SCHEMBL342956 | 0.79 | CDK1 (0.39) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL343818 | 0.78 | CDK2 (0.46) | JAK2TYK2JAK3 | |
| SCHEMBL15428785 | 0.78 | CDK2 (0.46) | JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | CHUK, MAP2K2, CDK3 | JAK1 79/4885JAK2 217/4885TYK2 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.