Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 7/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
| ▸ | BRAF | P15056 | 11/20 | 0.60 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.60 |
| ▸ | RAF1 | P04049 | 2/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.60 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.60 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.60 |
| ▸ | NEK2 | P51955 | 2/20 | 0.60 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.60 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.60 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.60 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.60 |
| ▸ | NEK11 | Q8NG66 | 2/20 | 0.60 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.60 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.60 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | PIR | O00625 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3430662 | 0.87 | BRAF (0.62) | CYP2C19CYP2C9CYP3A4BRAFRIPK2 | |
| SCHEMBL1771897 | 0.86 | BRAF (0.80) | BRAFRIPK2RAF1KDRMAP2K2 | |
| SCHEMBL3431424 | 0.80 | BRAF (0.59) | BRAF | |
| SCHEMBL298514 | 0.80 | BRAF (0.75) | CYP2C19CYP2C9CYP3A4BRAFRIPK2 | |
| SCHEMBL298692 | 0.79 | BRAF (0.78) | CYP2C19CYP2C9CYP3A4BRAFRIPK2 | |
| SCHEMBL1772520 | 0.79 | BRAF (0.84) | BRAFRIPK2RAF1KDRMAP2K2 | |
| SCHEMBL1772225 | 0.77 | BRAF (0.80) | CYP2C19BRAFRIPK2RAF1KDR | |
| SCHEMBL298479 | 0.77 | BRAF (0.79) | CYP2C19CYP2C9CYP3A4BRAFRIPK2 | |
| SCHEMBL1772313 | 0.76 | BRAF (0.79) | BRAFRIPK2RAF1KDRMAP2K2 | |
| SCHEMBL1772878 | 0.76 | BRAF (0.88) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265608-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009111278-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2009-09-11 | — | — | WO | disclosed |