Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT4 | P35916 | 4/20 | 0.72 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.72 |
| ▸ | FLT3 | P36888 | 3/20 | 0.72 |
| ▸ | AURKA | O14965 | 12/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | CSK | P41240 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3429978 | 0.93 | FLT4 (0.68) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL3427462 | 0.92 | FLT4 (0.75) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL3428228 | 0.92 | FLT4 (0.74) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL2051044 | 0.90 | AURKA (0.57) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL3428897 | 0.89 | PDGFRB (0.56) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL3426544 | 0.87 | FLT4 (0.67) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL2052845 | 0.86 | FLT4 (0.82) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL2050465 | 0.85 | FLT4 (0.70) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL2051279 | 0.85 | FLT4 (0.81) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL2049132 | 0.85 | AURKA (0.60) | FLT4PDGFRBFLT3AURKACSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7691867-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2010-04-06 | — | — | US | disclosed |
| EP-1613619-B1 | QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-03-26 | — | — | EP | disclosed |
| EP-1613619-A1 | QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER | AstraZeneca AB (SE) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004094410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-11-04 | — | — | WO | disclosed |