Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.79 |
| ▸ | S1PR3 | Q99500 | 9/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.69 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2121492 | 0.95 | S1PR1 (0.82) | S1PR1S1PR3KCNH2S1PR5 | |
| SCHEMBL2129722 | 0.94 | S1PR1 (0.77) | S1PR1S1PR3KCNH2S1PR5 | |
| SCHEMBL2605709 | 0.93 | S1PR1 (0.76) | S1PR1S1PR3KCNH2S1PR5 | |
| SCHEMBL2132654 | 0.92 | S1PR1 (0.74) | S1PR1S1PR3KCNH2S1PR5 | |
| SCHEMBL13012762 | 0.90 | S1PR1 (0.72) | S1PR1S1PR3KCNH2S1PR5 | |
| SCHEMBL2602144 | 0.89 | S1PR1 (0.78) | S1PR1S1PR3KCNH2S1PR5 | |
| SCHEMBL2121313 | 0.88 | S1PR1 (1.00) | S1PR1S1PR3KCNH2S1PR5 | |
| SCHEMBL2130411 | 0.88 | S1PR1 (0.77) | S1PR1S1PR3KCNH2S1PR5 | |
| SCHEMBL2121714 | 0.88 | S1PR1 (1.00) | S1PR1S1PR3KCNH2S1PR5 | |
| SCHEMBL2121586 | 0.88 | S1PR1 (0.79) | S1PR1S1PR3KCNH2S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010146105-A1 | S1P1 AGONISTS COMPRISING A BICYCLIC N-CONTAINING RING | GLAXO GROUP LIMITED (GB) | 2010-12-23 | — | — | WO | claimed |
| WO-2010146105-A1 | S1P1 AGONISTS COMPRISING A BICYCLIC N-CONTAINING RING | GLAXO GROUP LIMITED (GB) | 2010-12-23 | — | — | WO | disclosed |