SCHEMBL3430504

SCHEMBL3430504

N#C/C(=C\c1cc2ccc3cc(/C=C(\C#N)c4ccc(C(F)(F)F)cc4)cc4ccc(c1)c2c34)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO2 P16083 4/20 0.49
ESR1 P03372 2/20 0.45
ESR2 Q92731 2/20 0.45
MAPT P10636 4/20 0.43
TP53 P04637 1/20 0.43
GAA P10253 1/20 0.43
PTGS1 P23219 4/20 0.42
NQO1 P15559 1/20 0.41
RPS6KA3 P51812 1/20 0.38
JAK3 P52333 1/20 0.38
PTGS2 P35354 2/20 0.38
FTO Q9C0B1 1/20 0.36
NPC1 O15118 1/20 0.36
ALDH1A1 P00352 1/20 0.36
MAPK1 P28482 1/20 0.36
RAB9A P51151 1/20 0.36
KDM4E B2RXH2 1/20 0.36
CES2 O00748 1/20 0.36
CES1 P23141 1/20 0.36
TUBB4A P04350 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3430503 0.90 ESR1 (0.50) NQO2ESR1ESR2MAPTTP53
SCHEMBL3430554 0.87 ESR1 (0.47) NQO2ESR1ESR2MAPTTP53
SCHEMBL3430983 0.87 ESR1 (0.47) NQO2ESR1ESR2MAPTTP53
SCHEMBL21517807 0.84 ESR1 (0.62) NQO2ESR1ESR2MAPTTP53
SCHEMBL248048 0.84 ESR1 (0.62) NQO2ESR1ESR2MAPTTP53
SCHEMBL24236835 0.84 ESR1 (0.62) NQO2ESR1ESR2MAPTTP53
SCHEMBL2759685 0.84 CYP1A2 (0.38) NQO2ESR1ESR2MAPTTP53
SCHEMBL3432101 0.80 ESR1 (0.57) NQO2ESR1ESR2MAPTTP53
SCHEMBL3433649 0.80 ESR1 (0.57) NQO2ESR1ESR2MAPTTP53
SCHEMBL21517824 0.80 ESR1 (0.57) NQO2ESR1ESR2MAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8674347-B2 Organic semiconductor material and organic thin-film transistor KYUSHU INSTITUTE OF TECHNOLOGY (JP) 2014-03-18 US disclosed
US-20120001162-A1 ORGANIC SEMICONDUCTOR MATERIAL AND ORGANIC THIN-FILM TRANSISTOR KYUSHU INSTITUTE OF TECHNOLOGY (JP) 2012-01-05 US disclosed