Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777828 | 1.00 | HDAC1 (0.70) | HDAC1KCNH2HDAC8HDAC6HDAC3 | |
| SCHEMBL1777829 | 1.00 | HDAC1 (0.70) | HDAC1KCNH2HDAC8HDAC6HDAC3 | |
| SCHEMBL1777824 | 1.00 | HDAC1 (0.70) | HDAC1KCNH2HDAC8HDAC6HDAC3 | |
| SCHEMBL1778534 | 0.91 | HDAC1 (0.72) | HDAC1KCNH2HDAC8HDAC6KDM1A | |
| SCHEMBL1778479 | 0.91 | HDAC1 (0.72) | HDAC1KCNH2HDAC8HDAC6KDM1A | |
| SCHEMBL1778538 | 0.91 | HDAC1 (0.72) | HDAC1KCNH2HDAC8HDAC6KDM1A | |
| SCHEMBL1778481 | 0.91 | HDAC1 (0.72) | HDAC1KCNH2HDAC8HDAC6KDM1A | |
| SCHEMBL1778483 | 0.91 | HDAC1 (0.72) | HDAC1KCNH2HDAC8HDAC6KDM1A | |
| SCHEMBL3430933 | 0.91 | HDAC1 (0.72) | HDAC1KCNH2HDAC8HDAC6KDM1A | |
| SCHEMBL1779219 | 0.88 | HDAC1 (0.69) | HDAC1KCNH2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102036955-B | Hydroxamate-based inhibitors of deacetylase B | NOVARTIS AG | 2013-03-27 | — | — | CN | claimed |
| CN-102036955-B | Hydroxamate-based inhibitors of deacetylase B | NOVARTIS AG | 2013-03-27 | — | — | CN | disclosed |
| EP-2260020-A1 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B | Novartis AG (CH) | 2010-12-15 | — | — | EP | disclosed |
| WO-2009118305-A1 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B | NOVARTIS AG (CH) | 2009-10-01 | — | — | WO | disclosed |