Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 4/20 | 0.38 |
| ▸ | CD44 | P16070 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11007041 | 0.72 | HTR2A (0.76) | HTR2ACYP3A4MEN1CYP2D6KMT2A | |
| Hydrochloric Acid SCHEMBL29960806 | 0.71 | HTR2A (0.97) | HTR2ACYP3A4MEN1CYP2D6KMT2A | |
| SCHEMBL980093 | 0.71 | MEN1 (0.75) | HTR2ACYP3A4MEN1CYP2D6KMT2A | |
| SCHEMBL19164320 | 0.71 | MEN1 (0.69) | HTR2ACYP3A4MEN1CYP2D6KMT2A | |
| SCHEMBL1076323 | 0.70 | CYP3A4 (1.00) | HTR2ACYP3A4MEN1CYP2D6KMT2A | |
| SCHEMBL15096889 | 0.70 | CYP3A4 (1.00) | HTR2ACYP3A4MEN1CYP2D6KMT2A | |
| SCHEMBL1099172 | 0.69 | HTR2A (0.66) | HTR2ACYP3A4MEN1CYP2D6KMT2A | |
| SCHEMBL6391686 | 0.66 | HTR2A (0.60) | HTR2ACYP3A4MEN1CYP2D6KMT2A | |
| SCHEMBL2026301 | 0.66 | MEN1 (0.56) | HTR2ACYP3A4MEN1CYP2D6KMT2A | |
| SCHEMBL329949 | 0.66 | HTR2C (0.67) | HTR2ACYP3A4MEN1CYP2D6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100273772-A1 | Bisaryl Alkynylamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 (MGLUR5) | WYETH LLC (US) | 2010-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273772-A1 | Bisaryl Alkynylamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 (MGLUR5) | GRM5, GRM1, GRM2 | HTR2A 166/4885CYP3A4 3209/4885MEN1 3561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.