Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1780449 | 1.00 | HDAC1 (0.50) | HDAC1KCNH2HTTCA12CA1 | |
| SCHEMBL1780445 | 1.00 | HDAC1 (0.50) | HDAC1KCNH2HTTCA12CA1 | |
| SCHEMBL1780451 | 1.00 | HDAC1 (0.50) | HDAC1KCNH2HTTCA12CA1 | |
| SCHEMBL1777283 | 0.89 | HDAC1 (0.62) | HDAC1KCNH2KDM1AHDAC8HDAC6 | |
| SCHEMBL1780069 | 0.89 | HDAC1 (0.62) | HDAC1KCNH2KDM1AHDAC8HDAC6 | |
| SCHEMBL1777279 | 0.89 | HDAC1 (0.62) | HDAC1KCNH2KDM1AHDAC8HDAC6 | |
| SCHEMBL1777282 | 0.89 | HDAC1 (0.62) | HDAC1KCNH2KDM1AHDAC8HDAC6 | |
| SCHEMBL1780100 | 0.87 | HDAC1 (0.46) | HDAC1KCNH2HTTCA12CA1 | |
| SCHEMBL1780097 | 0.87 | HDAC1 (0.46) | HDAC1KCNH2HTTCA12CA1 | |
| SCHEMBL3432931 | 0.87 | HDAC1 (0.46) | HDAC1KCNH2HTTCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2260020-A1 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B | Novartis AG (CH) | 2010-12-15 | — | — | EP | disclosed |
| WO-2009118305-A1 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B | NOVARTIS AG (CH) | 2009-10-01 | — | — | WO | disclosed |