Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433299 | 0.81 | POLB (0.41) | POLBCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL30023899 | 0.74 | PTPN2 (0.47) | POLBCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL16488549 | 0.72 | POLB (0.43) | POLBCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL16488553 | 0.72 | POLB (0.43) | POLBCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL3129177 | 0.70 | POLB (0.42) | POLBCHRM2CHRM4CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL2517408 | 0.69 | POLB (0.39) | POLBCHRM2CHRM4CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL2517411 | 0.69 | POLB (0.39) | POLBCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL2519039 | 0.66 | PTPN2 (0.46) | POLBCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL6522269 | 0.66 | PTPN2 (0.46) | POLBCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL2515505 | 0.66 | PTPN2 (0.46) | POLBCHRM2CHRM4CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250155-A1 | 5H-CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009089462-A1 | 5H-CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |