Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 20/20 | 0.83 |
| ▸ | PIM3 | Q86V86 | 20/20 | 0.83 |
| ▸ | PIM2 | Q9P1W9 | 20/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2692505 | 0.91 | PIM1 (1.00) | PIM1PIM3PIM2 | |
| SCHEMBL4123974 | 0.91 | PIM1 (1.00) | PIM1PIM3PIM2 | |
| SCHEMBL2691725 | 0.85 | PIM1 (1.00) | PIM1PIM3PIM2 | |
| SCHEMBL12687517 | 0.84 | PIM1 (0.78) | PIM1PIM3PIM2 | |
| SCHEMBL2694153 | 0.83 | PIM1 (1.00) | PIM1PIM3PIM2 | |
| SCHEMBL2694159 | 0.83 | PIM1 (1.00) | PIM1PIM3PIM2 | |
| SCHEMBL16754173 | 0.80 | PIM1 (0.75) | PIM1PIM3PIM2 | |
| SCHEMBL12079359 | 0.80 | PIM2 (0.75) | PIM1PIM3PIM2 | |
| SCHEMBL15600417 | 0.80 | PIM1 (0.70) | PIM1PIM3PIM2 | |
| SCHEMBL12079450 | 0.78 | PIM2 (0.72) | PIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262802-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis AG (CH) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009109576-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2009-09-11 | — | — | WO | disclosed |