Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 12/20 | 0.70 |
| ▸ | SCN1A | P35498 | 2/20 | 0.64 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.64 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL252707 | 0.83 | SCN5A (1.00) | SCN5ASCN1ASCN2AGPR139CASP3 | |
| SCHEMBL317497 | 0.81 | SCN5A (0.84) | SCN5ASCN1ASCN2ACASP3S1PR1 | |
| SCHEMBL252058 | 0.79 | SCN5A (1.00) | SCN5ASCN1ASCN2AGPR139 | |
| SCHEMBL252480 | 0.77 | SCN5A (1.00) | SCN5ASCN1ASCN2AGPR139 | |
| SCHEMBL252450 | 0.77 | SCN5A (0.88) | SCN5ASCN1ASCN2AGPR139 | |
| SCHEMBL253931 | 0.76 | SCN5A (0.83) | SCN5ASCN1ASCN2AGPR139 | |
| SCHEMBL252119 | 0.76 | SCN5A (0.77) | SCN5ASCN1ASCN2AGPR139GRM2 | |
| SCHEMBL252947 | 0.74 | SCN5A (0.77) | SCN5ASCN1ASCN2AGPR139 | |
| SCHEMBL318208 | 0.74 | SCN5A (0.67) | SCN5ASCN1ASCN2AGPR139GRM2 | |
| SCHEMBL253720 | 0.72 | SCN5A (0.77) | SCN5ASCN1ASCN2AGPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003392-A1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |