Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 4/20 | 0.65 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3429990 | 0.93 | ESR2 (0.54) | ESR2NR1H2HDAC6NPC1RAB9A | |
| SCHEMBL587184 | 0.86 | ESR2 (0.62) | ESR2NR1H2MAPK1ABHD6HDAC1 | |
| SCHEMBL29676899 | 0.86 | ESR2 (0.62) | ESR2NR1H2MAPK1ABHD6HDAC1 | |
| SCHEMBL29964782 | 0.82 | NR1H2 (0.61) | ESR2NR1H2MAPK1ABHD6HDAC1 | |
| SCHEMBL2515678 | 0.82 | NR1H2 (0.61) | ESR2NR1H2MAPK1ABHD6HDAC1 | |
| SCHEMBL2118099 | 0.79 | ESR2 (0.52) | ESR2NR1H2DDB1CRBNNPC1 | |
| SCHEMBL450677 | 0.79 | ESR2 (1.00) | ESR2NR1H2MAPK1ABHD6HDAC1 | |
| SCHEMBL2095898 | 0.79 | ESR2 (0.76) | ESR2NR1H2MAPK1ABHD6HDAC1 | |
| SCHEMBL29590844 | 0.79 | ESR2 (1.00) | ESR2NR1H2MAPK1ABHD6HDAC1 | |
| SCHEMBL2056208 | 0.79 | ESR2 (0.76) | ESR2NR1H2MAPK1ABHD6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094979-A1 | THIAZOLE OR THIADIZALOE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS | GLAXO WELLCOME HOUSE (GB) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094979-A1 | THIAZOLE OR THIADIZALOE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS | S1PR1, S1PR5, S1PR2 | ESR2 1161/4885NR1H2 32/4885MAPK1 1264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.