Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 19/20 | 0.62 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.46 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PTGIR | P43119 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL136272 | 0.86 | PTGDR2 (0.81) | PTGDR2TBXA2RPTGDRCYP3A4CYP2C9 | |
| SCHEMBL142599 | 0.79 | PTGDR2 (0.70) | PTGDR2TBXA2RPTGDRCYP3A4CYP2C9 | |
| SCHEMBL3433655 | 0.78 | PTGDR2 (0.49) | PTGDR2TBXA2RPTGDRCYP3A4SMN1; SMN2 | |
| SCHEMBL137332 | 0.78 | PTGDR2 (0.68) | PTGDR2TBXA2RPTGDRCYP3A4CYP2C9 | |
| SCHEMBL137772 | 0.78 | PTGDR2 (0.70) | PTGDR2TBXA2RPTGDRCYP3A4CYP2C9 | |
| SCHEMBL135309 | 0.77 | PTGDR2 (0.78) | PTGDR2TBXA2RPTGDRCYP3A4CYP2C9 | |
| SCHEMBL16558833 | 0.76 | PTGDR2 (0.76) | PTGDR2TBXA2RPTGDRCYP3A4CYP2C9 | |
| Am-211 SCHEMBL138450 | 0.76 | PTGDR2 (1.00) | PTGDR2TBXA2RPTGDRCYP3A4CYP2C9 | |
| Am-211 SCHEMBL29433664 | 0.76 | PTGDR2 (1.00) | PTGDR2TBXA2RPTGDRCYP3A4CYP2C9 | |
| SCHEMBL143473 | 0.76 | PTGDR2 (0.89) | PTGDR2TBXA2RPTGDRCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245002-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009099901-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |