Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 16/20 | 0.58 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.53 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2749834 | 0.91 | EGFR (0.57) | EGFRERBB2ERBB4ERBB3GAK | |
| SCHEMBL2748385 | 0.88 | EGFR (0.58) | EGFRERBB2ERBB4ERBB3GAK | |
| SCHEMBL2748057 | 0.82 | EGFR (0.63) | EGFRERBB2ERBB4ERBB3GAK | |
| SCHEMBL2749626 | 0.80 | EGFR (0.61) | EGFRERBB2ERBB4ERBB3GAK | |
| SCHEMBL2748762 | 0.80 | ERBB2 (0.55) | EGFRERBB2ERBB4ERBB3GAK | |
| SCHEMBL4562801 | 0.79 | EGFR (0.70) | EGFRERBB2ERBB4ERBB3GAK | |
| SCHEMBL2748695 | 0.78 | EGFR (0.58) | EGFRERBB2ERBB4ERBB3GAK | |
| SCHEMBL2749408 | 0.78 | EGFR (0.58) | EGFRERBB2ERBB4ERBB3GAK | |
| SCHEMBL2749939 | 0.76 | EGFR (0.57) | EGFRERBB2ERBB4ERBB3GAK | |
| SCHEMBL3355374 | 0.76 | EGFR (0.65) | EGFRERBB2ERBB4ERBB3GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036910-A1 | HEART PROTECTION BY ADMINISTERING AN AMP-ACTIVATED PROTEIN KINASE ACTIVATOR | OHTA YOSHIKAZU (JP) | 2010-04-01 | — | — | WO | disclosed |