Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 12/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | FER | P16591 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1045593 | 0.84 | ZAP70 (0.63) | ZAP70LRRK2ABCG2 | |
| SCHEMBL1043547 | 0.81 | ZAP70 (0.54) | ZAP70JAK2 | |
| SCHEMBL1048594 | 0.80 | ZAP70 (0.59) | ZAP70JAK2FERABCG2 | |
| SCHEMBL12960742 | 0.80 | ZAP70 (0.56) | ZAP70JAK2FERLRRK2 | |
| SCHEMBL1050028 | 0.79 | ZAP70 (0.66) | ZAP70JAK2FERLRRK2BRAF | |
| SCHEMBL1045472 | 0.77 | ZAP70 (0.61) | ZAP70JAK2 | |
| SCHEMBL12928852 | 0.75 | ZAP70 (0.60) | ZAP70JAK2LRRK2BRAFABCG2 | |
| SCHEMBL1045909 | 0.75 | ZAP70 (0.58) | ZAP70BRAFTNNI3K | |
| SCHEMBL1045352 | 0.74 | ZAP70 (0.59) | ZAP70LRRK2ABCG2 | |
| SCHEMBL1063443 | 0.74 | ZAP70 (0.51) | ZAP70BRAFTNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |