Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.87 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1773272 | 0.93 | BRAF (1.00) | BRAF | |
| SCHEMBL3429848 | 0.92 | BRAF (0.87) | BRAF | |
| SCHEMBL3431914 | 0.88 | BRAF (0.87) | BRAF | |
| SCHEMBL3430445 | 0.87 | BRAF (0.87) | BRAF | |
| SCHEMBL1772009 | 0.85 | BRAF (1.00) | BRAF | |
| SCHEMBL1772569 | 0.85 | BRAF (1.00) | BRAF | |
| SCHEMBL1771981 | 0.84 | BRAF (0.79) | BRAF | |
| SCHEMBL1772408 | 0.84 | BRAF (0.84) | BRAF | |
| SCHEMBL1772027 | 0.81 | BRAF (1.00) | BRAF | |
| SCHEMBL1772294 | 0.81 | BRAF (1.00) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265608-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009111278-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2009-09-11 | — | — | WO | disclosed |