Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.32 |
| ▸ | CYP46A1 | Q9Y6A2 | 5/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11898914 | 0.89 | MAPT (0.36) | KDM4EGPR119CYP46A1SSTR4PIM1 | |
| SCHEMBL4433671 | 0.89 | MAPT (0.36) | KDM4EGPR119CYP46A1SSTR4PIM1 | |
| SCHEMBL1710280 | 0.89 | MAPT (0.36) | KDM4EGPR119CYP46A1SSTR4PIM1 | |
| SCHEMBL4444653 | 0.85 | MAPT (0.39) | — | |
| SCHEMBL11898761 | 0.85 | MAPT (0.39) | — | |
| SCHEMBL11898762 | 0.85 | MAPT (0.39) | — | |
| SCHEMBL4444646 | 0.85 | MAPT (0.39) | — | |
| SCHEMBL4444713 | 0.85 | MAPT (0.39) | — | |
| SCHEMBL4444705 | 0.85 | MAPT (0.39) | — | |
| SCHEMBL4438024 | 0.81 | MAPT (0.36) | KDM4EPIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262802-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis AG (CH) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009109576-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2009-09-11 | — | — | WO | disclosed |