Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 18/20 | 0.53 |
| ▸ | FER | P16591 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1044894 | 0.88 | ZAP70 (0.58) | ZAP70FER | |
| SCHEMBL3394062 | 0.87 | ZAP70 (0.60) | ZAP70 | |
| SCHEMBL1049082 | 0.85 | ZAP70 (0.71) | ZAP70FER | |
| SCHEMBL1047910 | 0.84 | ZAP70 (0.64) | ZAP70 | |
| SCHEMBL1045966 | 0.84 | ZAP70 (0.52) | ZAP70 | |
| SCHEMBL1047320 | 0.83 | ZAP70 (0.53) | ZAP70 | |
| SCHEMBL1045390 | 0.83 | ZAP70 (0.58) | ZAP70FER | |
| SCHEMBL1048279 | 0.83 | ZAP70 (0.57) | ZAP70FER | |
| SCHEMBL1045571 | 0.82 | ZAP70 (0.55) | ZAP70FERLRRK2 | |
| SCHEMBL1048263 | 0.82 | ZAP70 (0.56) | ZAP70FER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |