Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3434725 | 1.00 | ALK (0.55) | ALK | |
| SCHEMBL3433578 | 0.84 | ALK (0.49) | ALK | |
| SCHEMBL675901 | 0.84 | ALK (0.50) | ALK | |
| SCHEMBL675900 | 0.84 | ALK (0.50) | ALK | |
| SCHEMBL3432176 | 0.84 | DRD3 (0.43) | ALK | |
| SCHEMBL3721483 | 0.84 | NPC1 (0.41) | ALK | |
| SCHEMBL3721481 | 0.84 | NPC1 (0.41) | ALK | |
| SCHEMBL3432174 | 0.84 | DRD3 (0.43) | ALK | |
| SCHEMBL676199 | 0.84 | ALK (0.66) | ALK | |
| SCHEMBL676198 | 0.84 | ALK (0.66) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010025872-A2 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2010-03-11 | — | — | WO | disclosed |
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |