Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PDE2A | O00408 | 2/20 | 0.47 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535795 | 1.00 | EGLN1 (0.63) | EGLN1ALDH1A1MAPK1KDM4EHPGD | |
| SCHEMBL3405250 | 1.00 | EGLN1 (0.63) | EGLN1ALDH1A1MAPK1KDM4EHPGD | |
| SCHEMBL12851536 | 0.93 | EGLN1 (0.54) | EGLN1ALDH1A1MAPK1KDM4EHPGD | |
| SCHEMBL4537749 | 0.92 | EGLN1 (0.55) | EGLN1ALDH1A1MAPK1KDM4EHPGD | |
| SCHEMBL3409508 | 0.92 | EGLN1 (0.64) | EGLN1PDE2A | |
| SCHEMBL3407323 | 0.92 | EGLN1 (0.54) | EGLN1ALDH1A1MAPK1KDM4EHPGD | |
| SCHEMBL3409543 | 0.92 | EGLN1 (0.54) | EGLN1ALDH1A1MAPK1KDM4EHPGD | |
| SCHEMBL3409110 | 0.92 | EGLN1 (0.64) | EGLN1PDE2A | |
| SCHEMBL3408585 | 0.92 | EGLN1 (0.64) | EGLN1PDE2A | |
| SCHEMBL3409470 | 0.91 | EGLN1 (0.54) | EGLN1ALDH1A1MAPK1PDE2AMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257539-A1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | Merck Sharp & Dohme Corp. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009117269-A1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | MERCK & CO., INC. (US) | 2009-09-24 | — | — | WO | disclosed |