Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | TYK2 | P29597 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BCL9 | O00512 | 2/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL204967 | 0.75 | LCK (0.46) | SMN1; SMN2NPC1RAB9AJAK2JAK1 | |
| SCHEMBL29138124 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AJAK2JAK1 | |
| SCHEMBL206309 | 0.73 | HSD17B10 (0.55) | SMN1; SMN2NPC1RAB9AHTTHSD11B1 | |
| SCHEMBL1441223 | 0.72 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9AJAK2JAK1 | |
| SCHEMBL20129713 | 0.72 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9AJAK2JAK1 | |
| SCHEMBL3678408 | 0.71 | TMEM97 (0.57) | SMN1; SMN2NPC1RAB9ACYP2C19TMEM97 | |
| SCHEMBL11916703 | 0.71 | PDE4B (0.57) | SMN1; SMN2NPC1RAB9AJAK2JAK1 | |
| SCHEMBL22765331 | 0.71 | TMEM97 (0.57) | SMN1; SMN2NPC1RAB9ACYP2C19TMEM97 | |
| SCHEMBL27678403 | 0.71 | PDE4B (0.57) | SMN1; SMN2NPC1RAB9AJAK2JAK1 | |
| SCHEMBL4982385 | 0.71 | PDE4B (0.55) | SMN1; SMN2NPC1RAB9AJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247600-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Lead Therapeutics, Inc. (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009099736-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |