Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17667832 | 0.94 | SMN1; SMN2 (0.40) | SMN1; SMN2ALDH1A1MEN1KMT2ASMO | |
| SCHEMBL1062403 | 0.93 | SMO (0.46) | SMN1; SMN2ALDH1A1MEN1KMT2ASMO | |
| SCHEMBL1061051 | 0.91 | SMO (0.40) | SMN1; SMN2ALDH1A1MEN1KMT2ASMO | |
| SCHEMBL1063930 | 0.91 | USP30 (0.42) | MEN1KMT2A | |
| SCHEMBL3425434 | 0.85 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL1062284 | 0.82 | SMO (0.40) | SMN1; SMN2ALDH1A1MEN1KMT2ASMO | |
| SCHEMBL10314493 | 0.82 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MEN1KMT2ASMO | |
| SCHEMBL1062302 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPK1 | |
| Hydrochloric Acid SCHEMBL1079829 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MEN1KMT2ASMO | |
| SCHEMBL10314231 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1MEN1KMT2ASMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247588-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009107850-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-03 | — | — | WO | disclosed |