Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 15/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3436333 | 0.91 | NOTUM (0.60) | NOTUMMAPTTSHR | |
| SCHEMBL7444262 | 0.91 | NOTUM (0.60) | NOTUMMAPTTSHR | |
| SCHEMBL3436316 | 0.90 | TSHR (0.58) | NOTUMMAPTTSHR | |
| SCHEMBL3436354 | 0.87 | MAPT (0.60) | NOTUMMAPTTSHR | |
| SCHEMBL3436359 | 0.86 | NOTUM (0.54) | NOTUMMAPTTSHR | |
| SCHEMBL14125452 | 0.81 | NOTUM (1.00) | NOTUM | |
| SCHEMBL1704630 | 0.81 | NOTUM (0.72) | NOTUM | |
| SCHEMBL19049632 | 0.81 | TSHR (0.58) | NOTUMMAPTTSHR | |
| SCHEMBL2935666 | 0.81 | NOTUM (0.62) | NOTUMKEAP1NFE2L2 | |
| SCHEMBL28061420 | 0.80 | NOTUM (0.70) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107428736-A | Oneself chemotactic element inhibitor | 癌症研究科技有限公司 | 2017-12-01 | — | — | CN | disclosed |
| CN-102803252-B | Be used for the treatment of indole amides derivative and the related compound thereof of neurodegenerative disorders | K.U. LEUVEN RESEARCH & DEVELOPMENT (BE) | 2016-05-25 | — | — | CN | disclosed |
| CN-102574789-A | Pyrrolidinone carboxamide derivatives as chemokine-R (CHEMR23) modulators | CHEMOCENTRYX INC | 2012-07-11 | — | — | CN | disclosed |
| US-8163746-B2 | Azolecarboxamide derivative | ASTELLAS PHARMA INC. (JP) | 2012-04-24 | — | — | US | disclosed |
| US-8163746-B2 | Azolecarboxamide derivative | ASTELLAS PHARMA INC. (JP) | 2012-04-24 | — | — | US | disclosed |
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2009-11-19 | — | — | US | disclosed |
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2009-11-19 | — | — | US | disclosed |
| CN-101516372-A | Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators | ATHERSYS INC (US) | 2009-08-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | GPR17, NTRK1, TRPV1 | NOTUM 3349/4885MAPT 1330/4885TSHR 867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.