Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C2A | O00443 | 1/20 | 0.54 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 16/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 16/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3436414 | 0.82 | PIK3C2A (0.55) | PIK3C2APIK3C2BHCRTR1HCRTR2CYP3A4 | |
| SCHEMBL3436521 | 0.79 | PIK3C2A (0.52) | PIK3C2APIK3C2BHCRTR1HCRTR2CYP3A4 | |
| SCHEMBL3435893 | 0.78 | PIK3C2A (0.54) | PIK3C2APIK3C2BHCRTR1HCRTR2CYP3A4 | |
| SCHEMBL3433906 | 0.76 | PIK3C2A (0.41) | PIK3C2APIK3C2BLRRK2HCRTR1HCRTR2 | |
| SCHEMBL3433338 | 0.75 | PIK3C2A (0.41) | PIK3C2APIK3C2BLRRK2HCRTR1HCRTR2 | |
| SCHEMBL3433343 | 0.75 | PIK3C2A (0.41) | PIK3C2APIK3C2BLRRK2HCRTR1HCRTR2 | |
| SCHEMBL3431129 | 0.74 | PIK3C2A (0.43) | PIK3C2APIK3C2BHCRTR1HCRTR2CYP3A4 | |
| SCHEMBL945486 | 0.72 | PIK3C2A (0.81) | PIK3C2APIK3C2B | |
| SCHEMBL14802016 | 0.71 | PIK3C2A (0.81) | PIK3C2APIK3C2B | |
| SCHEMBL3435552 | 0.71 | PIK3C2A (0.40) | PIK3C2APIK3C2BLRRK2HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010146351-A1 | INDOLYLMETHYL-MORPHOLINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-12-23 | — | — | WO | disclosed |