Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Desipramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 6/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 8/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | HTR2A | P28223 | 4/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 4/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 4/20 | 1.00 |
| ▸ | DRD2 | P14416 | 4/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 4/20 | 1.00 |
| ▸ | HRH1 | P35367 | 4/20 | 1.00 |
| ▸ | DRD3 | P35462 | 4/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 3/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 3/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 3/20 | 1.00 |
| ▸ | HTR2C | P28335 | 3/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 3/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 3/20 | 1.00 |
| ▸ | HTR2B | P41595 | 3/20 | 1.00 |
| ▸ | MTOR | P42345 | 3/20 | 1.00 |
| ▸ | CACNA1B | Q00975 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Desipramine SCHEMBL5072939 | 1.00 | SLC6A4 (1.00) | SLC6A4SLC6A2CYP3A4HTR2ACHRM2 | |
| Desipramine SCHEMBL29379525 | 1.00 | SLC6A4 (1.00) | SLC6A4SLC6A2CYP3A4HTR2ACHRM2 | |
| Desipramine SCHEMBL41992 | 0.98 | SLC6A2 (1.00) | SLC6A4SLC6A2CYP3A4HTR2ACHRM2 | |
| Desipramine SCHEMBL2944786 | 0.98 | SLC6A2 (1.00) | SLC6A4SLC6A2CYP3A4HTR2ACHRM2 | |
| Desipramine SCHEMBL5501781 | 0.98 | SLC6A2 (1.00) | SLC6A4SLC6A2CYP3A4HTR2ACHRM2 | |
| Desipramine SCHEMBL29085912 | 0.98 | SLC6A4 (0.97) | SLC6A4SLC6A2CYP3A4HTR2ACHRM2 | |
| Desipramine SCHEMBL29364790 | 0.98 | SLC6A2 (1.00) | SLC6A4SLC6A2CYP3A4HTR2ACHRM2 | |
| Desipramine SCHEMBL41993 | 0.97 | SLC6A4 (0.94) | SLC6A4SLC6A2CYP3A4HTR2ACHRM2 | |
| Desipramine SCHEMBL28105338 | 0.91 | SLC6A4 (0.83) | SLC6A4SLC6A2CYP3A4HTR2ACHRM2 | |
| Desipramine SCHEMBL27517227 | 0.91 | SLC6A4 (0.83) | SLC6A4SLC6A2CYP3A4HTR2ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 37741 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| CN-121753757-B | Construction method and application of parkinsonism animal model for improving survival rate | 杭州市第一人民医院(西湖大学附属杭州市第一人民医院) | 2026-05-15 | — | — | CN | claimed |
| US-12624036-B2 | Method of treating post-traumatic stress disorder | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-05-12 | — | — | US | claimed |
| US-12624037-B2 | Method of treating agitation, aggressive behavior, and impulse control disorder | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-05-12 | — | — | US | claimed |
| US-12617809-B2 | Cardioprotective lipid and method of use | SIGNPATH PHARMA, INC. (US) | 2026-05-05 | — | — | US | claimed |
| US-12616691-B2 | Use of fatty acid oxidation inhibitors as antimicrobials | WASHINGTON UNIVERSITY IN ST. LOUIS (US) | 2026-05-05 | — | — | US | claimed |
| US-12594388-B2 | Device to deliver a predetermined amount of a substance to a natural orifice of the body | APTARGROUP, INC. (US) | 2026-04-07 | — | — | US | claimed |
| US-20260092932-A1 | METHODS AND COMPOSITIONS FOR THE DETECTION, DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDER | THE JOHNSON CENTER FOR CHILD HEALTH AND DEV (US) | 2026-04-02 | — | — | US | claimed |
| US-4310524-A | TCA Composition and method for rapid onset antidepressant therapy | RICHARDSON-MERRELL, INC. (US) | 1982-01-12 | — | — | US | claimed |
| US-4279992-A | Specific binding assay employing an enzyme-cleavable substrate as label | MILES LABORATORIES, INC. (US) | 1981-07-21 | — | — | US | claimed |
| EP-0022771-A4 | RADIO RECEPTOR ASSAY FOR BENZODIAZEPINES IN PLASMA AND OTHER BIOLOGICAL SPECIMENS. | US HEALTH (US) | 1981-02-04 | — | — | EP | claimed |
| US-4249003-A | Process for polycyclic amines | AKTIEBOLAGET LEO (SE) | 1981-02-03 | — | — | US | claimed |
| EP-0022771-A1 | RADIO RECEPTOR ASSAY FOR BENZODIAZEPINES IN PLASMA AND OTHER BIOLOGICAL SPECIMENS | THE UNITED STATES OF AMERICA, represented by DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1981-01-28 | — | — | EP | claimed |
| US-4207307-A | Simultaneous immunoassay of multiple antigens and assay for cocaine metabolites | RESEARCH CORPORATION (US) | 1980-06-10 | — | — | US | claimed |
| WO-1980000750-A1 | RADIO RECEPTOR ASSAY FOR BENZODIZAPINES IN PLASMA AND OTHER BIOLOGICAL SPECIMENS | US COMMERCE (US) | 1980-04-17 | — | — | WO | claimed |
| US-4175119-A | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs | PORTER GARRY L | 1979-11-20 | — | — | US | claimed |
| US-4172074-A | Preparation of an antidepressant | AKTIEBOLAGET LEO (SE) | 1979-10-23 | — | — | US | claimed |
| US-3961060-A | DOPA, M-TYROSINE, APOMORPHINE, PIPERAZINE DERIVATIVE | ASTRA LAKEMEDAL AKTIEBOLAG (SW) | 1976-06-01 | — | — | US | claimed |