Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CFTR | P13569 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | MLNR | O43193 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL982260 | 0.85 | CFTR (0.55) | KDM4EALDH1A1HTTCFTRNPC1 | |
| SCHEMBL985091 | 0.85 | MAPK1 (0.66) | KDM4EALDH1A1RAB9AHPGDLMNA | |
| SCHEMBL981153 | 0.83 | CFTR (0.64) | KDM4EALDH1A1HTTCFTRNPC1 | |
| SCHEMBL979635 | 0.81 | CFTR (0.64) | KDM4EALDH1A1CFTRHPGDLMNA | |
| SCHEMBL982499 | 0.77 | MAPK1 (0.75) | KDM4EALDH1A1HPGDLMNAMAPK1 | |
| SCHEMBL979729 | 0.75 | MAPK1 (0.68) | KDM4EALDH1A1HTTNPC1RAB9A | |
| SCHEMBL981905 | 0.74 | KDM4E (0.55) | KDM4EALDH1A1HTTCFTRNPC1 | |
| SCHEMBL980773 | 0.74 | CFTR (0.64) | KDM4EALDH1A1HTTCFTRHPGD | |
| SCHEMBL981894 | 0.74 | KDM4E (0.74) | KDM4EALDH1A1HTTNPC1RAB9A | |
| SCHEMBL981613 | 0.73 | CFTR (0.67) | KDM4EALDH1A1CFTRHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247580-A1 | QUINOXALINONE DERIVATIVES AS INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES | Merck Patent GmbH (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009109258-A1 | QUINOXALINONE DERIVATIVES AS INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2009-09-11 | — | — | WO | disclosed |