Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.74 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.74 |
| ▸ | AURKA | O14965 | 2/20 | 0.74 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.74 |
| ▸ | SLC2A1 | P11166 | 4/20 | 0.69 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.60 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.55 |
| ▸ | BRAF | P15056 | 3/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 8/20 | 0.49 |
| ▸ | EGFR | P00533 | 6/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | FYN | P06241 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3441995 | 0.92 | AURKA (0.63) | KDRAURKBAURKACDK19SLC2A1 | |
| SCHEMBL3442668 | 0.91 | AURKA (0.76) | KDRAURKBAURKACDK19SLC2A1 | |
| SCHEMBL3442956 | 0.88 | AURKA (0.71) | KDRAURKBAURKACDK19SLC2A1 | |
| SCHEMBL13105597 | 0.88 | AURKA (0.77) | KDRAURKBAURKACDK19SLC2A1 | |
| SCHEMBL3442649 | 0.86 | AURKA (0.79) | KDRAURKBAURKACDK19SLC2A1 | |
| SCHEMBL13105438 | 0.86 | SLC2A1 (0.82) | KDRAURKBAURKACDK19SLC2A1 | |
| SCHEMBL3442634 | 0.86 | SLC2A1 (0.82) | KDRAURKBAURKACDK19SLC2A1 | |
| SCHEMBL3441765 | 0.85 | SLC2A1 (0.77) | KDRAURKBAURKACDK19SLC2A1 | |
| SCHEMBL3442268 | 0.85 | SLC2A1 (0.76) | KDRAURKBAURKACDK19SLC2A1 | |
| SCHEMBL3443005 | 0.85 | AURKA (1.00) | KDRAURKBAURKACDK19SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7812022-B2 | 2-pyrimidinyl pyrazolopyridine ErbB kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2010-10-12 | — | — | US | claimed |
| EP-1828185-B1 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2009-05-06 | — | — | EP | claimed |
| US-20080051395-A1 | 2-Pyrimidinyl Pyrazolopyridine Erbb Kinase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2008-02-28 | — | — | US | claimed |
| US-7812022-B2 | 2-pyrimidinyl pyrazolopyridine ErbB kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2010-10-12 | — | — | US | disclosed |
| US-7812022-B2 | 2-pyrimidinyl pyrazolopyridine ErbB kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2010-10-12 | — | — | US | disclosed |
| US-7812022-B2 | 2-pyrimidinyl pyrazolopyridine ErbB kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2010-10-12 | — | — | US | disclosed |
| EP-1828185-B1 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2009-05-06 | — | — | EP | disclosed |
| US-20080051395-A1 | 2-Pyrimidinyl Pyrazolopyridine Erbb Kinase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051395-A1 | 2-Pyrimidinyl Pyrazolopyridine Erbb Kinase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2008-02-28 | — | — | US | disclosed |
| US-20080051395-A1 | 2-Pyrimidinyl Pyrazolopyridine Erbb Kinase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051395-A1 | 2-Pyrimidinyl Pyrazolopyridine Erbb Kinase Inhibitors | ERBB2, ERBB3, ERBB4 | KDR 11/4885AURKB 228/4885AURKA 168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.