SCHEMBL3442192

SCHEMBL3442192

O=c1c(-c2ccc(Cl)cc2)nc2cccnc2n1CC(F)F.O=c1c(-c2ccc(Cl)cc2)nc2cccnc2n1CC1CC1

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 10/20 0.43
USP2 O75604 8/20 0.43
CYP3A4 P08684 6/20 0.43
CYP2C9 P11712 5/20 0.43
MAPK1 P28482 2/20 0.43
CYP2C19 P33261 4/20 0.42
HSD17B10 Q99714 8/20 0.42
ALDH1A1 P00352 7/20 0.42
CASP1 P29466 6/20 0.42
CASP7 P55210 6/20 0.42
CYP2D6 P10635 2/20 0.42
HPGD P15428 2/20 0.42
TSHR P16473 2/20 0.42
HIF1A Q16665 3/20 0.42
ALOX15 P16050 2/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL928338 0.92 CYP1A2 (0.48) CYP1A2USP2CYP3A4CYP2C9MAPK1
SCHEMBL927672 0.91 CYP1A2 (0.50) CYP1A2USP2CYP3A4CYP2C9MAPK1
SCHEMBL930164 0.85 PDE5A (0.48) CYP1A2USP2CYP3A4CYP2C9MAPK1
SCHEMBL928327 0.82 CYP1A2 (0.50) CYP1A2USP2CYP3A4CYP2C9MAPK1
SCHEMBL928088 0.82 CYP1A2 (0.46) CYP1A2USP2CYP3A4CYP2C9MAPK1
SCHEMBL15457502 0.81 CYP1A2 (0.41) CYP1A2USP2CYP3A4CYP2C9MAPK1
SCHEMBL927333 0.81 CYP1A2 (0.48) CYP1A2USP2CYP3A4CYP2C9MAPK1
SCHEMBL927678 0.81 CFTR (0.50) CYP3A4ALDH1A1
SCHEMBL15457510 0.79 CYP1A2 (0.45) CYP1A2USP2CYP3A4CYP2C9MAPK1
SCHEMBL929077 0.78 CFTR (0.52) CYP1A2USP2CYP3A4CYP2C9MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2247292-A1 PYRIDOPYRAZINONES DERIVATIVES INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES Merck Patent GmbH (DE) 2010-11-10 EP disclosed
WO-2009109341-A1 PYRIDOPYRAZINONES DERIVATIVES INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES MERCK PATENT GMBH (DE) 2009-09-11 WO disclosed