Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 13/20 | 1.00 |
| ▸ | HDAC8 | Q9BY41 | 13/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 6/20 | 1.00 |
| ▸ | HDAC4 | P56524 | 6/20 | 1.00 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 6/20 | 1.00 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 1.00 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 1.00 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 1.00 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3445139 | 1.00 | HDAC1 (1.00) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL3445133 | 1.00 | HDAC1 (1.00) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL3446430 | 0.89 | HDAC1 (0.80) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL3446429 | 0.89 | HDAC1 (0.80) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL3446426 | 0.89 | HDAC1 (0.80) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL3444589 | 0.88 | HDAC3 (0.79) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL3444587 | 0.88 | HDAC3 (0.79) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL3444584 | 0.88 | HDAC3 (0.79) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL3445327 | 0.84 | HDAC1 (0.71) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL3445321 | 0.84 | HDAC1 (0.71) | HDAC1HDAC8HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816386-B2 | Cinnamic, phenylpropiolic and phenylpropanoic acid derivatives useful as anti-tumor agents | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2010-10-19 | — | — | US | claimed |
| US-20080194659-A1 | Cinnamic, Phenylpropiolic and Phenylpropanoic Acid Derivatives Useful as Anti-Tumor Agents | SIGMA-TAU FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-08-14 | — | — | US | claimed |
| EP-1893561-A1 | CINNAMIC, PHENYLPROPIOLIC AND PHENYLPROPANOIC ACID DERIVATIVES USEFUL AS ANTI-TUMOUR AGENTS | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2008-03-05 | — | — | EP | claimed |
| WO-2006131482-A1 | CINNAMIC, PHENYLPROPIOLIC AND PHENYLPROPANOIC ACID DERIVATIVES USEFUL AS ANTI-TUMOUR AGENTS | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-12-14 | — | — | WO | claimed |
| US-7816386-B2 | Cinnamic, phenylpropiolic and phenylpropanoic acid derivatives useful as anti-tumor agents | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2010-10-19 | — | — | US | disclosed |
| US-20080194659-A1 | Cinnamic, Phenylpropiolic and Phenylpropanoic Acid Derivatives Useful as Anti-Tumor Agents | SIGMA-TAU FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194659-A1 | Cinnamic, Phenylpropiolic and Phenylpropanoic Acid Derivatives Useful as Anti-Tumor Agents | ABCC1, VHL, ABCB1 | HDAC1 493/4885HDAC8 845/4885HDAC6 1707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.